Journal
NATURE REVIEWS CLINICAL ONCOLOGY
Volume 10, Issue 1, Pages 14-26Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrclinonc.2012.204
Keywords
-
Categories
Funding
- National Institute of Health [K24-CA125440, R01-CA129371, R01-CA117079-02, R01-CA57683]
- American Academy of Neurology Foundation
- Stephen E. & Catherine Pappas Cancer Research Foundation
- NATIONAL CANCER INSTITUTE [K24CA125440, R01CA057683, R21CA117079, R01CA129371] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Glioblastomas are heterogeneous neoplasms that are driven by complex signalling pathways, and are among the most aggressive and challenging cancers to treat. Despite standard treatment with resection, radiation and chemotherapy, the prognosis of patients with glioblastomas remains poor. An increasing understanding of the molecular pathogenesis of glioblastomas has stimulated the development of novel therapies, including the use of molecular-targeted agents. Identification and validation of diagnostic, prognostic and predictive biomarkers has led to the advancement of clinical trial design, and identification of glioblastoma subgroups with a more-favourable prognosis and response to therapy. In this Review, we discuss common molecular alterations relevant to the biology of glioblastomas, targeted, antiangiogenic and immunotherapies that have impacted on the treatment of this disease, and the challenges and pitfalls associated with these therapies. In addition, we emphasize current biomarkers relevant to the management of patients with glioblastoma. Tanaka, S. et al. Nat. Rev. Clin. Oncol. 10, 14-26 (2013); published online 27 November 2012; doi:10.1038/nrclinonc.2012.204
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available