Journal
SMALL
Volume 11, Issue 43, Pages 5790-5799Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201501345
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Funding
- Sheikh Zayed Institute-Clark School of Engineering seed grant
- National Science Foundation [CBET0966407]
- Maryland Innovation Initiative from the Maryland Technology Development Corporation [0114012]
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Liposomes represent a leading class of nanoparticles for drug delivery. While a variety of techniques for liposome synthesis have been reported that take advantage of microfluidic flow elements to achieve precise control over the size and polydispersity of nanoscale liposomes, with important implications for nanomedicine applications, these methods suffer from extremely limited throughput, making them impractical for large-scale nanoparticle synthesis. High aspect ratio microfluidic vertical flow focusing is investigated here as a new approach to overcoming the throughput limits of established microfl uidic nanoparticle synthesis techniques. Here the vertical flow focusing technique is utilized to generate populations of small, unilamellar, and nearly monodisperse liposomal nanoparticles with exceptionally high production rates and remarkable sample homogeneity. By leveraging this platform, liposomes with modal diameters ranging from 80 to 200 nm are prepared at production rates as high as 1.6 mg min(-1) in a simple flow-through process.
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