Journal
SMALL
Volume 11, Issue 19, Pages 2275-2283Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201403249
Keywords
photoacoustic imaging; photothermal therapy; CuS; nanodots
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Funding
- National Basic Research Program of China (973 Program) [2011CB707905]
- China National Funds for Distinguished Young Scientists [51225202]
- National Natural Science Foundation of China [51132009, 81371570]
- Program of Shanghai Subject Chief Scientist [14XD1403800]
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Monodisperse, ultrasmall (<5 nm) Cu2-xS nanodots (u-Cu2-xS NDs) with significantly strong near-infrared absorption and conversion are successfully demonstrated for effective deep-tissue photoacoustic imaging-guided photothermal therapy both in vitro and in vivo. Owing to ultrasmall nanoparticle size and high water dispersibility as well as long stability, such nanodots possess a prolonged circulation in blood and good passive accumulation within tumors through the enhanced permeability and retention effect. These u-Cu2-xS NDs have negligible side effects to both blood and normal tissues according to in vivo toxicity evaluations for up to 3 months, showing excellent hemo/histocompatibility. Furthermore, these u-Cu2-xS NDs can be thoroughly cleared through feces and urine within 5 days, showing high biosafety for further potential clinical translation. This novel photoacoustic imaging-guided photothermal therapy based on u-Cu2-xS NDs composed of a single component shows great prospects as a multifunctional nanoplatform with integration and multifunction for cancer diagnosis and therapy.
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