Journal
SMALL
Volume 11, Issue 40, Pages 5360-5368Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201501573
Keywords
cellular uptake; DNA-brush block copolymers; gene regulation; micelles; spherical nucleic acids
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Funding
- Center for Cancer Nanotechnology Excellence (CCNE) initiative of National Institutes of Health (NIH) [U54 CA119341, U54 CA151880]
- Dixon Translational Research Grants Initiative
- Defense Advanced Research Planning Agency [N66001-11-1-4189]
- Croucher Foundation
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By grafting multiple DNA strands onto one terminus of a polyester chain, a DNA-brush block copolymer that can assemble into micelle structure is constructed. These micelle spherical nucleic acids have a density of nucleic acids that is substantively higher than linear DNA block copolymer structures, which makes them effective cellular transfection and intracellular gene regulation agents.
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