4.6 Review

Pharmacological strategies for lowering LDL cholesterol: statins and beyond

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

A PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo

Yan G. Ni et al.

JOURNAL OF LIPID RESEARCH (2011)

Editorial Material Cardiac & Cardiovascular Systems

An update on the IMProved Reduction of Outcomes: Vytorin Efficacy International Trial (IMPROVE-IT) design

Robert M. Califf et al.

AMERICAN HEART JOURNAL (2010)

Review Biochemistry & Molecular Biology

Do structural differences in statins correlate with clinical efficacy? Lorenzo Arnaboldi and Alberto Corsini

Lorenzo Arnaboldi et al.

CURRENT OPINION IN LIPIDOLOGY (2010)

Review Biochemistry & Molecular Biology

Lipid lowering with thyroid hormone and thyromimetics

Bo Angelin et al.

CURRENT OPINION IN LIPIDOLOGY (2010)

Review Chemistry, Medicinal

Strategies for proprotein convertase subtilisin kexin 9 modulation: a perspective on recent patents

Marianne Abifadel et al.

EXPERT OPINION ON THERAPEUTIC PATENTS (2010)

Article Biochemistry & Molecular Biology

A new method for measurement of total plasma PCSK9: clinical applications

Genevieve Dubuc et al.

JOURNAL OF LIPID RESEARCH (2010)

Article Cardiac & Cardiovascular Systems

Efficacy and Safety of Mipomersen, an Antisense Inhibitor of Apolipoprotein B, in Hypercholesterolemic Subjects Receiving Stable Statin Therapy

Fatima Akdim et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2010)

Article Medicine, General & Internal

Use of the Thyroid Hormone Analogue Eprotirome in Statin-Treated Dyslipidemia

Paul W. Ladenson et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Editorial Material Cardiac & Cardiovascular Systems

The ACCORD Study Group. Effects of combination lipid therapy in type 2 diabetes mellitus.

Lukasz Januszkiewicz

KARDIOLOGIA POLSKA (2010)

Article Medicine, General & Internal

Effects of Combination Lipid Therapy in Type 2 Diabetes Mellitus

Henry N. Ginsberg et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Article Cardiac & Cardiovascular Systems

Efficacy and Safety of ABT-335 (Fenofibric Acid) in Combination With Atorvastatin in Patients With Mixed Dyslipidemia

Anne C. Goldberg et al.

AMERICAN JOURNAL OF CARDIOLOGY (2009)

Review Biochemistry & Molecular Biology

What's the deal with niacin development: is laropiprant add-on therapy a winning strategy to beat a straight flush?

Harold E. Bays et al.

CURRENT OPINION IN LIPIDOLOGY (2009)

Article Endocrinology & Metabolism

Lowering Low-Density Lipoprotein Cholesterol: Statins, Ezetimibe, Bile Acid Sequestrants, and Combinations: Comparative Efficacy and Safety

Runhua Hou et al.

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA (2009)

Review Cardiac & Cardiovascular Systems

Colesevelam hydrochloride: usefulness of a specifically engineered bile acid sequestrant for lowering LDL-cholesterol

Alberto Corsini et al.

EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION (2009)

Article Medicine, General & Internal

Major Lipids, Apolipoproteins, and Risk of Vascular Disease

The Emerging Risk Factors Collaboration*

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2009)

Article Biochemistry & Molecular Biology

Function and distribution of circulating human PCSK9 expressed extrahepatically in transgenic mice

Yi Luo et al.

JOURNAL OF LIPID RESEARCH (2009)

Review Biotechnology & Applied Microbiology

Thyroid hormone mimetics: potential applications in atherosclerosis, obesity and type 2 diabetes

John D. Baxter et al.

NATURE REVIEWS DRUG DISCOVERY (2009)

Article Medicine, General & Internal

Rosuvastatin and Cardiovascular Events in Patients Undergoing Hemodialysis

Bengt C. Fellstroem et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

Letter Multidisciplinary Sciences

Reply to Chesson et al.: Carbon stable isotopes in beef differ distinctly between corporations

Hope Jahren et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Multidisciplinary Sciences

A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates

Joyce C. Y. Chan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Medicine, General & Internal

Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein

Paul M. Ridker et al.

NEW ENGLAND JOURNAL OF MEDICINE (2008)

Article Multidisciplinary Sciences

Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

Maria Frank-Kamenetsky et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Cardiac & Cardiovascular Systems

Inhibition of microsomal triglyceride transfer protein alone or with ezetimibe in patients with moderate hypercholesterolemia

Frederick F. Samaha et al.

NATURE CLINICAL PRACTICE CARDIOVASCULAR MEDICINE (2008)

Article Cardiac & Cardiovascular Systems

Molecular diagnosis of hypobetalipoproteinemia: An ENID review

Patrizia Tarugi et al.

ATHEROSCLEROSIS (2007)

Article Medicine, General & Internal

Rosuvastatin in older patients with systolic heart failure

John Kjekshus et al.

NEW ENGLAND JOURNAL OF MEDICINE (2007)

Article Biochemistry & Molecular Biology

Secreted PCSK9 promotes LDL receptor degradation independently of proteolytic activity

Jun Li et al.

BIOCHEMICAL JOURNAL (2007)

Article Biochemistry & Molecular Biology

Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice

Mark J. Graham et al.

JOURNAL OF LIPID RESEARCH (2007)

Article Pharmacology & Pharmacy

Prescription omega-3 fatty acids for the treatment of hypertriglyceridemia

James M. McKenney et al.

AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY (2007)

Article Medicine, General & Internal

Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia

Marina Cuchel et al.

NEW ENGLAND JOURNAL OF MEDICINE (2007)

Review Cardiac & Cardiovascular Systems

European guidelines on cardiovascular disease prevention in clinical practice: Full text

Ian Graham et al.

EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION (2007)

Article Medicine, General & Internal

Sequence variations in PCSK9, low LDL, and protection against coronary heart disease

JC Cohen et al.

NEW ENGLAND JOURNAL OF MEDICINE (2006)

Article Genetics & Heredity

A spectrum of PCSK9 Alleles contributes to plasma levels of low-density lipoprotein cholesterol

IK Kotowski et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2006)

Article Genetics & Heredity

Molecular characterization of loss-of-function mutations in PCSK9 and identification of a compound heterozygote

Zhenze Zhao et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2006)

Article Medicine, General & Internal

High-dose atorvastatin vs usual dose simvastatin for secondary prevention after myocardial infarction - The IDEAL study: A randomized controlled trial

TR Pedersen et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2005)

Article Hematology

Hepatic and cardiovascular consequences of familial hypobetalipoproteinemia

RR Sankatsing et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2005)

Review Medicine, General & Internal

Nicotinic acid: the broad-spectrum lipid drug. A 50th anniversary review

LA Carlson

JOURNAL OF INTERNAL MEDICINE (2005)

Article Medicine, General & Internal

Atorvastatin in patients with type 2 diabetes mellitus undergoing hemodialysis

C Wanner et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)

Article Medicine, General & Internal

Intensive lipid lowering with atorvastatin in patients with stable coronary disease

JC LaRosa et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)

Article Medicine, General & Internal

Intensive versus moderate lipid lowering with statins after acute coronary syndromes

CP Cannon et al.

NEW ENGLAND JOURNAL OF MEDICINE (2004)

Review Biochemistry & Molecular Biology

Locked nucleic acid: A potent nucleic acid analog in therapeutics and biotechnology

JS Jepsen et al.

OLIGONUCLEOTIDES (2004)

Review Medicine, Research & Experimental

Progress in antisense technology

ST Crooke

ANNUAL REVIEW OF MEDICINE (2004)

Article Multidisciplinary Sciences

Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype

KN Maxwell et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Medicine, Research & Experimental

Monogenic hypercholesterolemia: new insights in pathogenesis and treatment

DJ Rader et al.

JOURNAL OF CLINICAL INVESTIGATION (2003)

Article Genetics & Heredity

Mutations in PCSK9 cause autosomal dominant hypercholesterolemia

M Abifadel et al.

NATURE GENETICS (2003)

Review Biochemistry & Molecular Biology

Antisense technologies - Improvement through novel chemical modifications

J Kurreck

EUROPEAN JOURNAL OF BIOCHEMISTRY (2003)

Article Cardiac & Cardiovascular Systems

Inhibition of intestinal cholesterol absorption by ezetimibe in humans

T Sudhop et al.

CIRCULATION (2002)

Article Cardiac & Cardiovascular Systems

ACC/AHA/NHLBI clinical advisory on the use and safety of statins

RC Pasternak et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2002)

Article Multidisciplinary Sciences

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

SM Elbashir et al.

NATURE (2001)