Journal
SMALL
Volume 11, Issue 37, Pages 4806-4822Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201500802
Keywords
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Categories
Funding
- Major State Basic Research Development Program of China (973 Program) [2014CB744503, 2013CB733802]
- National Natural Science Foundation of China (NSFC) [81422023, 81101101, 81371596, 51273165]
- Shenzhen municipal government [JCYJ20130401164750006]
- CUHK [4054012, 4054087, 1902062]
- Hong Kong RGC CRF [CUHK4/CRF/12G]
- Chinese Ministry of Education [212149]
- Fundamental Research Funds for the Central Universities, China [2013121039]
- Program for New Century Excellent Talents in University [NCET-13-0502]
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Metal-organic frameworks (MOFs), which are a unique class of hybrid porous materials built from metal ions and organic linkers, have attracted significant research interest in recent years. Compared with conventional porous materials, MOFs exhibit a variety of advantages, including a large surface area, a tunable pore size and shape, an adjustable composition and structure, biodegradability, and versatile functionalities, which enable MOFs to perform as promising platforms for drug delivery, molecular imaging, and theranostic applications. In this article, the recent research progress related to nanoscale metal-organic frameworks (NMOFs) is summarized with a focus on synthesis strategies and drug delivery, molecular imaging, and theranostic applications. The future challenges and opportunities of NMOFs are also discussed in the context of translational medical research. More effort is warranted to develop clinically translatable NMOFs for various applications in nanomedicine.
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