Journal
SMALL
Volume 12, Issue 5, Pages 668-677Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201502754
Keywords
melanin; micelles; polycatechols; contrast agents; relaxivity
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Funding
- NIH (NIBIB) [R01EB011633]
- Director's New Innovator Award [DP2OD008724]
- Alfred P. Sloan Foundation
- Compagnia di San Paolo (CSP NANOPROGLY Project)
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Amphiphilic triblock copolymers containing Fe-III-catecholate complexes formulated as spherical- or cylindrical-shaped micellar nanoparticles (SMN and CMN, respectively) are described as new T-1-weighted agents with high relaxivity, low cytotoxicity, and long-term stability in biological fluids. Relaxivities of both SMN and CMN exceed those of established gadolinium chelates across a wide range of magnetic field strengths. Interestingly, shape-dependent behavior is observed in terms of the particles' interactions with HeLa cells, with CMN exhibiting enhanced uptake and contrast via magnetic resonance imaging (MRI) compared with SMN. These results suggest that control over soft nanoparticle shape will provide an avenue for optimization of particle-based contrast agents as biodiagnostics. The polycatechol nanoparticles are proposed as suitable for preclinical investigations into their viability as gadolinium-free, safe, and effective imaging agents for MRI contrast enhancement.
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