4.8 Article

Cell-Instructive Microgels with Tailor-Made Physicochemical Properties

Journal

SMALL
Volume 11, Issue 42, Pages 5647-5656

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201501001

Keywords

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Funding

  1. EU Framework 7 HEALTH Research Programme PluriMes
  2. SystemsX.ch RTD project StoNets
  3. ERC [StG_311422]
  4. Swiss National Science Foundation Singergia grant [CRSII3_147684]
  5. Swiss National Science Foundation (SNF) [CRSII3_147684] Funding Source: Swiss National Science Foundation (SNF)

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A microfluidic in vitro cell encapsulation platform to systematically test the effects of microenvironmental parameters on cell fate in 3D is developed. Multiple cell types including fibroblasts, embryonic stem cells, and cancer cells are incorporated in enzymatically cross-linked poly(ethylene glycol)-based microgels having defined and tunable mechanical and biochemical properties. Furthermore, different approaches to prevent cell escape from the microcapsules are explored and shown to substantially enhance the potential of this technology. Finally, coencapsulation of microgels within nondegradable gels allows cell viability, proliferation, and morphology to be studied in different microenvironmental conditions up to two weeks in culture.

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