Journal
SMALL
Volume 11, Issue 17, Pages 2080-2086Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201403315
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Funding
- Basic Research Program of Science and Technology Commission of Shanghai Municipality [14JC1491100]
- Program for New Century Excellent Talents in University of Ministry of Education of China [NCET-11-0138]
- Shanghai Pujiang Program [14PJD016]
- National Natural Science Foundation of China [21207038]
- Research Found for the Doctoral Program of Higher Education of China [20120076120027]
- Shanghai Chenguang Program [12CG25]
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Bone metastasis is a frequent and fatal complication of cancer that lacks effective clinical treatment. Photothermal therapy represents a new strategy for the destruction of multiple cancers. In this study, trifolium-like platinum nanoparticles (TPNs) with small size and excellent photothermal conversion property are prepared via a facile and green method. TPNs show minimal cytotoxicity on normal cell lines and kill cancer cells upon exposure to a near-infrared light. These nanoparticles effectively inhibit tumor growth and prevent osteolysis in a bone metastasis model. This study offers a promising strategy in the treatment of bone metastasis.
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