Journal
NATURE PROTOCOLS
Volume 4, Issue 10, Pages 1560-1564Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nprot.2009.125
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Funding
- Regional Council of Basse-Normandie
- University of Caen Basse-Normandie
- Centre National de la Recherche Scientifique
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Long-term functional deficits after a brain injury are difficult to assess in the mouse. If no deficit is observed, researchers could conclude either that the animal has fully recovered or that the tests they used were not appropriate or sensitive enough to the modality of the deficits. We present here a detailed protocol describing how to conduct an adhesive removal test for this species. It consists of applying adhesive tape on each forepaw of the animal and measuring the time-to-contact and the time-to-remove them. This behavior implies correct paw and mouth sensitivity (time-to-contact) and correct dexterity (time-to-remove). To decrease interindividual differences, we recommend a training session (1 week, 1 trial per day) before surgical procedures so that mice to reach optimal performances.
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