Journal
NATURE PHYSICS
Volume 5, Issue 1, Pages 64-67Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NPHYS1129
Keywords
-
Categories
Ask authors/readers for more resources
Moves are afoot to illuminate particles in flight with powerful X-ray bursts, to determine the structure of single molecules, viruses and nanoparticles. This would circumvent important limitations of current techniques, including the need to condense molecules into pure crystals. Proposals to reconstruct the molecular structure from diffraction 'snapshots' of unknown orientation, however, require similar to 1,000 times more signal than available from next-generation sources. Using a new approach, we demonstrate the recovery of the structure of a weakly scattering macromolecule at the anticipated next-generation X-ray source intensities. Our work closes a critical gap in determining the structure of single molecules and nanoparticles by X-ray methods, and opens the way to reconstructing the structure of spinning, or randomly oriented objects at extremely low signal levels.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available