Journal
NATURE PHOTONICS
Volume 8, Issue 2, Pages 153-159Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NPHOTON.2013.360
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Funding
- National Science Foundation (NSF) [1214848]
- National Institutes of Health (NIH) [5R01EB010244]
- NSF [ECS-0335765]
- CIAN NSF ERC [EEC-0812072]
- State of Arizona's TRIF
- Div Of Industrial Innovation & Partnersh
- Directorate For Engineering [1214848] Funding Source: National Science Foundation
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Stimulated Raman scattering microscopy allows label-free chemical imaging and has enabled exciting applications in biology, material science and medicine. It provides a major advantage in imaging speed over spontaneous Raman scattering and has improved image contrast and spectral fidelity compared to coherent anti-Stokes Raman scattering. Wider adoption of the technique has, however, been hindered by the need for a costly and environmentally sensitive tunable ultrafast dual-wavelength source. We present the development of an optimized all-fibre laser system based on the optical synchronization of two picosecond power amplifiers. To circumvent the high-frequency laser noise intrinsic to amplified fibre lasers, we have further developed a high-speed noise cancellation system based on voltage-subtraction autobalanced detection. We demonstrate uncompromised imaging performance of our fibre-laser-based scattering microscope with shot-noise-limited sensitivity and an imaging speed up to 1 frame s(-1).
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