Journal
SMALL
Volume 11, Issue 29, Pages 3575-3581Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201403718
Keywords
carbon nanodots; solvent-derived materials; fluorescence imaging; biomedical applications; imaging
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Funding
- National Key Basic Research Program of China (973 Program) [2013CB932502]
- National Natural Science Foundation of China [21303022]
- Zhuo Xue Talent Plan of Fudan University
- Natural Science Foundation of Shanghai City of China [13ZR1451400]
- Sino-German Research Project [GZ995]
- Fudan University
- Nantong University
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Cancer imaging requires biocompatible and bright contrast-agents with selective and high accumulation in the tumor region but low uptake in normal tissues. Herein, 1-methyl-2-pyrrolidinone (NMP)-derived polymer-coated nitrogen-doped carbon nanodots (pN-CNDs) with a particle size in the range of 5-15 nm are prepared by a facile direct solvothermal reaction. The as-prepared pN-CNDs exhibit stable and adjustable fluorescence and excellent water solubility. Results of a cell viability test (CCK-8) and histology analysis both demonstrate that the pN-CNDs have no obvious cytotoxicity. Most importantly, the pN-CNDs can expediently enter glioma cells in vitro and also mediate glioma fluorescence imaging in vivo with good contrast via elevated passive targeting.
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