Journal
NATURE PHOTONICS
Volume 3, Issue 9, Pages 503-509Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NPHOTON.2009.157
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Funding
- NATIONAL CANCER INSTITUTE [U54CA136398] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB000712, R01EB008085] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS046214] Funding Source: NIH RePORTER
- NCI NIH HHS [U54 CA136398-01, U54 CA136398] Funding Source: Medline
- NIBIB NIH HHS [R01 EB000712-05, R01 EB008085, R01 EB008085-02, R01 EB000712] Funding Source: Medline
- NINDS NIH HHS [R01 NS046214-06, R01 NS046214] Funding Source: Medline
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Photoacoustic tomography (PAT) is probably the fastest-growing area of biomedical imaging technology, owing to its capacity for high-resolution sensing of rich optical contrast in vivo at depths beyond the optical transport mean free path (similar to 1 mm in human skin). Existing high-resolution optical imaging technologies, such as confocal microscopy and two-photon microscopy, have had a fundamental impact on biomedicine but cannot reach the penetration depths of PAT. By utilizing low ultrasonic scattering, PAT indirectly improves tissue transparency up to 1000-fold and consequently enables deeply penetrating functional and molecular imaging at high spatial resolution. Furthermore, PAT promises in vivo imaging at multiple length-scales; it can image subcellular organelles to organs with the same contrast origin-an important application in multiscale systems biology research.
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