Journal
NATURE NEUROSCIENCE
Volume 17, Issue 6, Pages 801-803Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.3706
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Funding
- European Research Council
- Swedish Research Council
- Swedish Heart and Lung Foundation
- Swedish Cancer Society
- Karolinska Institute
- Tobias Stiftelsen
- Strategic Research Programs in Stem Cells and Regenerative Medicine at Karolinska Institutet (StratRegen)
- AFA Forsdkringar
- Lund University (StemTherapy)
- European Union (project TargetBraIn [279017]
- Torsten Soderbergs Stiftelse
- Knut och Alice Wallenbergs Stiftelse
- German Research Foundation [Hu 1961/1-1]
- National Brain Research Programme (NAP), Hungary
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It has been unclear whether ischemic stroke induces neurogenesis or neuronal DNA rearrangements in the human neocortex. Using immunohistochemistry; transcriptome, genome and ploidy analyses; and determination of nuclear bomb test-derived C-14 concentration in neuronal DNA, we found neither to be the case. A large proportion of cortical neurons displayed DNA fragmentation and DNA repair a short time after stroke, whereas neurons at chronic stages after stroke showed DNA integrity, demonstrating the relevance of an intact genome for survival.
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