Journal
NATURE NEUROSCIENCE
Volume 17, Issue 5, Pages 661-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.3697
Keywords
-
Categories
Funding
- research grants from RIKEN Brain Science Institute
- Ministry of Education, Culture, Sports, Science and Technology
- Ministry of Health and Welfare
- grants-in-aid for the Molecular Imaging Program
- Japan Science and Technology Agency Precursory Research for Embryonic Science and Technology
- Cell Science Research Foundation
- Takeda Science Foundation
- Grants-in-Aid for Scientific Research [23680039, 26290019] Funding Source: KAKEN
Ask authors/readers for more resources
Experimental studies of Alzheimer's disease have largely depended on transgenic mice overexpressing amyloid precursor protein (APP). These mice, however, suffer from artificial phenotypes because, in addition to amyloid beta peptide (A beta), they overproduce other APP fragments. We generated knock-in mice that harbor Swedish and Beyreuther/Iberian mutations with and without the Arctic mutation in the APP gene. The mice showed typical A beta pathology, neuroinflammation and memory impairment in an age-dependent manner.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available