4.7 Article

Post-study caffeine administration enhances memory consolidation in humans

Journal

NATURE NEUROSCIENCE
Volume 17, Issue 2, Pages 201-203

Publisher

NATURE PUBLISHING GROUP
DOI: 10.1038/nn.3623

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Funding

  1. US National Institute on Aging [P50 AG05146, R01 AG034613]
  2. US National Science Foundation [CHE-1213438]
  3. Johns Hopkins University Provost Undergraduate Research Award
  4. Division Of Chemistry
  5. Direct For Mathematical & Physical Scien [1213438] Funding Source: National Science Foundation

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It is currently not known whether caffeine has an enhancing effect on long-term memory in humans. We used post-study caffeine administration to test its effect on memory consolidation using a behavioral discrimination task. Caffeine enhanced performance 24 h after administration according to an inverted U-shaped dose-response curve; this effect was specific to consolidation and not retrieval. We conclude that caffeine enhanced consolidation of long-term memories in humans.

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