Journal
NATURE NEUROSCIENCE
Volume 17, Issue 12, Pages 1658-1660Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.3843
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Funding
- Medical Research Council UK [MC_UU_12020/7]
- Medical Research Foundation [C0443]
- MRC [MC_UU_12020/7] Funding Source: UKRI
- Medical Research Council [1310807, MC_UU_12020/7] Funding Source: researchfish
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We found that optogenetic burst stimulation of hippocampal dopaminergic fibers from midbrain neurons in mice exploring novel environments enhanced the reactivation of pyramidal cell assemblies during subsequent sleep/rest. When applied during spatial learning of new goal locations, dopaminergic photostimulation improved the later recall of neural representations of space and stabilized memory performance. These findings reveal that midbrain dopaminergic neurons promote hippocampal network dynamics associated with memory persistence.
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