Journal
NATURE NEUROSCIENCE
Volume 17, Issue 9, Pages 1153-1155Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.3778
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Funding
- Duke University
- National Institute on Drug Abuse [DA03369, DA033369, DA031579]
- Howard Hughes Medical Institute International Student Research fellowship
- National Institute of Mental Health [MH078928, MH093612, MH084060, MH077159]
- [AA016274]
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We examined epigenetic regulation in regards to behaviorally and clinically relevant human brain function. Specifically, we found that increased promoter methylation of the serotonin transporter gene predicted increased threat-related amygdala reactivity and decreased mRNA expression in postmortem amygdala tissue. These patterns were independent of functional genetic variation in the same region. Furthermore, the association with amygdala reactivity was replicated in a second cohort and was robust to both sampling methods and age.
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