Journal
NATURE NEUROSCIENCE
Volume 17, Issue 10, Pages 1319-1321Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.3798
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Funding
- US National Institutes of Health [R01 MH098023, R01 MH087692, R01 DA036017, R01 NS21135]
- Hellman Family Faculty Fund
- Nielsen Corporation
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Substantial correlational evidence suggests that prefrontal regions are critical to honest and dishonest behavior, but causal evidence specifying the nature of this involvement remains absent. We found that lesions of the human dorsolateral prefrontal cortex (DLPFC) decreased the effect of honesty concerns on behavior in economic games that pit honesty motives against self-interest, but did not affect decisions when honesty concerns were absent. These results point to a causal role for DLPFC in honest behavior.
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