Journal
NATURE NEUROSCIENCE
Volume 17, Issue 6, Pages 804-806Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.3710
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Funding
- US National Institutes of Health [R01 NS081054, R01 MH091850]
- International Rett Syndrome Foundation
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Dysfunction in sensory information processing is a hallmark of many neurological disorders, including autism spectrum disorders, schizophrenia and Rett syndrome (RTT). Using mouse models of RTT, a monogenic disorder caused by mutations in MECP2, we found that the large-scale loss of MeCP2 from forebrain GABAergic interneurons led to deficits in auditory event-related potentials and seizure manifestation, whereas the restoration of MeCP2 in specific classes of interneurons ameliorated these deficits.
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