Journal
NATURE NEUROSCIENCE
Volume 16, Issue 12, Pages 1728-1730Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.3572
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Funding
- US National Institutes of Health [NS047344, ES021957, NS048271, HD069184]
- Brain & Behavior Research Foundation
- Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
- Maryland Stem Cell Research Fund
- Swiss National Science Foundation [PP00A-119026/1]
- The Brain & Behavior Research Foundationand Maryland Stem Cell Research Fund
- Fondation Leenaards
- Children's Tumor Foundation
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Using immunohistology, electron microscopy, electrophysiology and optogenetics, we found that proliferating adult mouse hippocampal neural precursors received immature GABAergic synaptic inputs from parvalbumin-expressing interneurons. Recently shown to suppress adult quiescent neural stem cell activation, parvalbumin interneuron activation promoted newborn neuronal progeny survival and development. Our results suggest a niche mechanism involving parvalbumin interneurons that couples local circuit activity to the diametric regulation of two critical early phases of adult hippocampal neurogenesis.
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