Journal
NATURE NEUROSCIENCE
Volume 17, Issue 1, Pages 27-29Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.3591
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Funding
- National Institute of Mental Health [R01 MH092306]
- Johnson & Johnson/International Mental Health Research Organization Rising Star Translational Research Award
- National Research Service Awards [F31 MH095425, F32 MH096464]
- NATIONAL INSTITUTE OF MENTAL HEALTH [F31MH095425, T32MH096678, P50MH096890, T32MH087004, R01MH092306, K99MH094405, F31MH108326, F32MH096464, R01MH051399] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM [R01AA022445] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [T32DA007135, R01DA014133] Funding Source: NIH RePORTER
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Mechanisms controlling release of brain-derived neurotrophic factor (BDNF) in the mesolimbic dopamine reward pathway remain unknown. We report that phasic optogenetic activation of this pathway increases BDNF amounts in the nucleus accumbens (NAc) of socially stressed mice but not of stress-naive mice. This stress gating of BDNF signaling is mediated by corticotrophin-releasing factor (CRF) acting in the NAc. These results unravel a stress context-detecting function of the brain's mesolimbic circuit.
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