Journal
NATURE NEUROSCIENCE
Volume 17, Issue 2, Pages 207-214Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.3610
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Funding
- US National Science Foundation
- Jane Coffin Childs Memorial Fund
- US National Institutes of Health (NIH)
- Harvard Stem Cell Institute
- Howard Hughes Medical Institute
- Helen Hay Whitney Foundation
- NIH [HD 32116, NS 28478]
- John G. Bowes Research Fund
- European Research Council [207807]
- UK Medical Research Council [86419]
- MRC [G0501173] Funding Source: UKRI
- European Research Council (ERC) [207807] Funding Source: European Research Council (ERC)
- Medical Research Council [G0501173] Funding Source: researchfish
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Throughout life, neural stem cells (NSCs) in different domains of the ventricular-subventricular zone (V-SVZ) of the adult rodent brain generate several subtypes of interneurons that regulate the function of the olfactory bulb. The full extent of diversity among adult NSCs and their progeny is not known. Here, we report the generation of at least four previously unknown olfactory bulb interneuron subtypes that are produced in finely patterned progenitor domains in the anterior ventral V-SVZ of both the neonatal and adult mouse brain. Progenitors of these interneurons are responsive to sonic hedgehog and are organized into microdomains that correlate with the expression domains of the Nkx6.2 and Zic family of transcription factors. This work reveals an unexpected degree of complexity in the specification and patterning of NSCs in the postnatal mouse brain.
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