Journal
NATURE NEUROSCIENCE
Volume 16, Issue 4, Pages 383-U191Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.3335
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Funding
- US National Institutes of Health [R01-MH079292, R01-DA016782, T32-AA009455, F32-DA026273]
- NARSAD
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Stressors affect dopamine-dependent behaviors such as motivation, although the underlying neurobiological mechanism is not well defined. We report that corticotropin-releasing factor (CRF) acts in the ventral tegmental area (VTA) to reduce the motivation to work for food rewards. CRF in the VTA regulates dopamine output in a stimulus- and pathway-specific manner, offering a mechanism by which acute stress selectively regulates information transmission via the VTA to reprioritize motivated behavior.
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