Journal
NATURE NEUROSCIENCE
Volume 16, Issue 12, Pages 1848-1856Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.3565
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Funding
- Australian Research Council [FT100100502, DP130101630]
- National Health and Medical Research Council [APP1004575]
- University of Queensland Early Career Researcher Award [2012003384]
- Australian Research Council [FT100100502] Funding Source: Australian Research Council
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Active dendritic integration is thought to enrich the computational power of central neurons. However, a direct role of active dendritic processing in the execution of defined neuronal computations in intact neural networks has not been established. Here we used multi-site electrophysiological recording techniques to demonstrate that active dendritic integration underlies the computation of direction selectivity in rabbit retinal ganglion cells. Direction-selective retinal ganglion cells fire action potentials in response to visual image movement in a preferred direction. Dendritic recordings revealed that preferred-direction moving-light stimuli led to dendritic spike generation in terminal dendrites, which were further integrated and amplified as they spread through the dendritic arbor to the axon to drive action potential output. In contrast, when light bars moved in a null direction, synaptic inhibition vetoed neuronal output by directly inhibiting terminal dendritic spike initiation. Active dendritic integration therefore underlies a physiologically engaged circuit-based computation in the retina.
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