Journal
NATURE NEUROSCIENCE
Volume 17, Issue 1, Pages 114-120Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.3598
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Funding
- National Research Service Award postdoctoral fellowship [F32 DC008932]
- US National Institutes of Health NIDCD Core [P30 DC011735]
- [R01 DC005782]
- [R01 DC012095]
- [R03 DC011373]
- [R01 DC013339]
- [T32 DC000014]
- NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES [UL1TR000043] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS [R01DC013339, P30DC011735, T32DC000014, R01DC005782, R03DC011373, R01DC012095, F32DC008932] Funding Source: NIH RePORTER
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Humans have similar to 400 intact odorant receptors, but each individual has a unique set of genetic variations that lead to variation in olfactory perception. We used a heterologous assay to determine how often genetic polymorphisms in odorant receptors alter receptor function. We identified agonists for 18 odorant receptors and found that 63% of the odorant receptors we examined had polymorphisms that altered in vitro function. On average, two individuals have functional differences at over 30% of their odorant receptor alleles. To show that these in vitro results are relevant to olfactory perception, we verified that variations in OR10G4 genotype explain over 15% of the observed variation in perceived intensity and over 10% of the observed variation in perceived valence for the high-affinity in vitro agonist guaiacol but do not explain phenotype variation for the lower-affinity agonists vanillin and ethyl vanillin.
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