Journal
NATURE NEUROSCIENCE
Volume 16, Issue 5, Pages 526-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.3372
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Funding
- Hilda and Preston Davis Foundation
- Ruth L. Kirschstein National Research Service Award
- Klarman Foundation
- Hirschl/Caulier Trust award
- US National Institutes of Health grants from the National Institute of General Medical Sciences
- National Institute on Deafness and Other Communication Disorders
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Animals can determine the nutritional value of sugar without the influence of taste. We examined a Drosophila mutant that is insensitive to the nutritional value of sugars, responding only to the concentration (that is, sweetness). The affected gene encodes a sodium/solute co-transporter-like protein, designated SLC5A11 (or cupcake), which is structurally similar to mammalian sodium/glucose co-transporters that transport sugar across the intestinal and renal lumen. However, SLC5A11 was prominently expressed in 10-13 pairs of R4 neurons of the ellipsoid body in the brain and functioned in these neurons for selecting appropriate foods.
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