Journal
NATURE NEUROSCIENCE
Volume 16, Issue 12, Pages 1734-1736Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.3576
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Funding
- US National Institutes of Health [RO1 DC04154, RO1 NS072406, P01 NS053862, F31DC010547, K01 NS069617, P30 DC10363, P30 NS069375]
- James S. McDonnell Foundation
- US National Science Foundation Graduate Research Fellowship Program
- US National Institutes of Health and Defense Advanced Research Projects Agency
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The climbing fiber input to the cerebellar cortex is thought to provide instructive signals that drive the induction of motor skill learning. We found that optogenetic activation of Purkinje cells, the sole output neurons of the cerebellar cortex, can also drive motor learning in mice. This dual control over the induction of learning by climbing fibers and Purkinje cells can expand the learning capacity of motor circuits.
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