Journal
NATURE NEUROSCIENCE
Volume 16, Issue 11, Pages 1523-1529Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.3537
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Funding
- US National Institutes of Health [NS-37956, CA-96832]
- Cancer Center Support grant [P30 CA21765]
- American Lebanese and Syrian Associated Charities of St. Jude Children's Research Hospital
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Active maintenance of genome stability is a prerequisite for the development and function of the nervous system. The high replication index during neurogenesis and the long life of mature neurons highlight the need for efficient cellular programs to safeguard genetic fidelity. Multiple DNA damage response pathways ensure that replication stress and other types of DNA lesions, such as oxidative damage, do not affect neural homeostasis. Numerous human neurologic syndromes result from defective DNA damage signaling and compromised genome integrity. These syndromes can involve different neuropathology, which highlights the diverse maintenance roles that are required for genome stability in the nervous system. Understanding how DNA damage signaling pathways promote neural development and preserve homeostasis is essential for understanding fundamental brain function.
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