Journal
NATURE NEUROSCIENCE
Volume 17, Issue 2, Pages 204-206Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.3609
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Funding
- Netherlands Organization for Scientific Research [NWO 918.66.613]
- European Research Council [ERC-2010-AdG 268800]
- Marie Curie Career Integration [FP7-PEOPLE-2011-CIG 304248]
- Spanish Ministry of Science and Innovation [SAF2011-27766]
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Despite accumulating evidence for a reconsolidation process in animals, support in humans, especially for episodic memory, is limited. Using a within-subjects manipulation, we found that a single application of electroconvulsive therapy following memory reactivation in patients with unipolar depression disrupted reactivated, but not non-reactivated, memories for an emotional episode in a time-dependent manner. Our results provide evidence for reconsolidation of emotional episodic memories in humans.
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