Journal
NATURE NEUROSCIENCE
Volume 16, Issue 7, Pages 845-U262Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.3401
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Funding
- Agence Nationale de la Recherche (ANR) [ANR-08-MNPS-018-01, ANR-09-BLAN-0267]
- CNRS Institut National des Sciences Biologiques (INSB)
- European Union [STREPS/NEST-APES 28594]
- Projets Exploratoires Premier Soutien (INSB)
- Fondation de la Recherche Medicale
- CNRS (INSB)
- Societe Francaise de Nutrition
- Institut Danone
- Douglas Foundation
- McGill University
- Canadian Fund for Innovation, Research Chair (Tier 2)
- Institute for Health Research
- Natural Science and Engineering Council of Canada
- Agence Nationale de la Recherche (ANR) [ANR-09-BLAN-0267] Funding Source: Agence Nationale de la Recherche (ANR)
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Ependymal cell cilia help move cerebrospinal fluid through the cerebral ventricles, but the regulation of their beat frequency remains unclear. Using in vitro, high-speed video microscopy and in vivo magnetic resonance imaging in mice, we found that the metabolic peptide melanin-concentrating hormone (MCH) positively controlled cilia beat frequency, specifically in the ventral third ventricle, whereas a lack of MCH receptor provoked a ventricular size increase.
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