Journal
NATURE NEUROSCIENCE
Volume 16, Issue 4, Pages 386-U195Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.3344
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Funding
- Netherlands Organization for Scientific Research ZON-MW VENI program [916.66.095]
- VENI grant from the Netherlands Organization for Scientific Research [016.115.196]
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Little is known about the underlying neural mechanism of deep brain stimulation (DBS). We found that DBS targeted at the nucleus accumbens (NAc) normalized NAc activity, reduced excessive connectivity between the NAc and prefrontal cortex, and decreased frontal low-frequency oscillations during symptom provocation in patients with obsessive-compulsive disorder. Our findings suggest that DBS is able to reduce maladaptive activity and connectivity of the stimulated region.
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