Journal
NATURE NEUROSCIENCE
Volume 15, Issue 8, Pages 1111-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.3151
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Funding
- Alexander von Humboldt Foundation
- ERC
- Deutsche Forschungsgemeinschaft [Sonderforschungsbereich (SFB) 488, SFB 636]
- Foundation for Science and Technology, Portugal
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Cognitive abilities decline in normal aging, yet the underlying molecular mechanisms are poorly understood. We found that aging was associated with a decrease in the expression of the DNA methyltransferase Dnmt3a2 in the hippocampus and that rescuing Dnmt3a2 levels restored cognitive functions. Moreover, we found that Dnmt3a2 is an activity-regulated immediate early gene that is partly dependent on nuclear calcium signaling and that hippocampal Dnmt3a2 levels determine cognitive abilities in both young adult and aged mice.
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