Journal
NATURE NEUROSCIENCE
Volume 15, Issue 12, Pages 1621-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.3263
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Funding
- US National Institutes of Health [R37-NS42925-10, P50-MH96890]
- Center core grant [5P30NS047463]
- National Multiple Sclerosis Society [FG1874-A-1]
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Protracted social isolation of adult mice induced behavioral, transcriptional and ultrastructural changes in oligodendrocytes of the prefrontal cortex (PFC) and impaired adult myelination. Social re-integration was sufficient to normalize behavioral and transcriptional changes. Short periods of isolation affected chromatin and myelin, but did not induce behavioral changes. Thus, myelinating oligodendrocytes in the adult PFC respond to social interaction with chromatin changes, suggesting that myelination acts as a form of adult plasticity.
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