Journal
NATURE NEUROSCIENCE
Volume 15, Issue 8, Pages 1102-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.3143
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Funding
- Medical Research Council [G0601503]
- European Community
- MRC [G0601503] Funding Source: UKRI
- Medical Research Council [G0601503] Funding Source: researchfish
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Optogenetic silencing using light-driven ion fluxes permits rapid and effective inhibition of neural activity. Using rodent hippocampal neurons, we found that silencing activity with a chloride pump can increase the probability of synaptically evoked spiking after photoactivation; this did not occur with a proton pump. This effect can be accounted for by changes to the GABA(A) receptor reversal potential and demonstrates an important difference between silencing strategies.
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