Journal
NATURE NEUROSCIENCE
Volume 15, Issue 9, Pages 1198-U43Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.3175
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Funding
- Volkswagen Foundation
- German National Academic Foundation
- Biotechnology and Biological Sciences Research Council [BB/G004455/1]
- German Science Foundation (DFG) [SFB889-A1]
- Biotechnology and Biological Sciences Research Council [BB/G004455/1] Funding Source: researchfish
- BBSRC [BB/G004455/1] Funding Source: UKRI
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The elusive transduction channels for hearing are directly gated mechanically by the pull of gating springs. We found that the transient receptor potential (TRP) channel TRPN1 (NOMPC) is essential for this direct gating of Drosophila auditory transduction channels and that the channel-spring complex was disrupted if TRPN1 was lost. Our results identify TRPN1 as a mechanical constituent of the fly's auditory transduction complex that may act as the channel and/or gating spring.
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