Journal
NATURE NEUROSCIENCE
Volume 15, Issue 3, Pages 370-372Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.3035
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Funding
- Swiss National Science Foundation
- Human Frontiers in Science Program
- SystemsX.ch
- Deutsche Forschungsgemeinschaft [Exc 257 NeuroCure]
- European Research Council
- Region Rhone-Alpes Exploradoc
- Agence Nationale de la Recherche France [ANR-09-JCJC-0028-01]
- Agence Nationale de la Recherche (ANR) [ANR-09-JCJC-0028] Funding Source: Agence Nationale de la Recherche (ANR)
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We investigated the impact of thalamus on ongoing cortical activity in the awake, behaving mouse. We demonstrate that the desynchronized cortical state during active behavior is driven by a centrally generated increase in thalamic action potential firing, which can also be mimicked by optogenetic stimulation of the thalamus. The thalamus therefore is key in controlling cortical states.
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