Primary oligodendrocyte death does not elicit anti-CNS immunity

Anti-myelin immunity is commonly thought to drive multiple sclerosis, yet the initial bigger of this autoreactivity remains elusive. One of the proposed factors for initiating this disease is the primary death of oligadendrecytess. To specifically test such oligodendrocyte death as a trigger for anti-CNS immunity, we inducibly killed olignodendrocytes in an in vivo manse model. Strong microglia-macrophage activation followed oligodendrocyte death, and myelin components in draining lymph nodes made CM antigens available to lymphocytes. However, even conditions farming countainity hystiander and memory removal of regadartoly T cells, presence of myelin-reactive T cells anti application of oligodendrocyte antibodies ad not result in the development of CNS inflammation after oligodendrocyte death. In addition, this lash of reactivity was not mediated by enhanced myelin-specific tolerance. Thus, in contrast with previously reputed in impaiments of oligodendroctye physiology, diffuse oligodendrocyte death alone or in conjunction with immune activation does not trigger immunity.