Journal
NATURE NEUROSCIENCE
Volume 14, Issue 12, Pages 1507-1509Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2954
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Funding
- National Institute on Alcohol Abuse
- Alcoholism Intramural Research Program [Z01-AA000411]
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Stress affects various forms of cognition. We found that moderate stress enhanced late reversal learning in a mouse touchscreen-based choice task. Ventromedial prefrontal cortex (vmPFC) lesions mimicked the effect of stress, whereas orbitofrontal and dorsolateral striatal lesions impaired reversal. Stress facilitation of reversal was prevented by BDNF infusion into the vmPFC. These findings suggest a mechanism by which stress-induced vmPFC dysfunction disinhibits learning by alternate (for example, striatal) systems.
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