Journal
NATURE NEUROSCIENCE
Volume 14, Issue 12, Pages 1599-U138Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2973
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Funding
- National Science Foundation [DMI0328162]
- US Department of Energy, Division of Materials Sciences through the Materials Research Laboratory and Center for Microanalysis of Materials at the University of Illinois at Urbana-Champaign [DE-FG02-07ER46471, DE-FG02-07ER46453]
- US National Institutes of Health (National Institute of Neurological Disorders and Stroke) [RO1-NS041811, RO1-NS48598]
- Citizens United for Research in Epilepsy
- Dr. Michel and Mrs. Anna Mirowski Discovery Fund for Epilepsy Research
- Ruth L. Kirschstein National Research Service from the US National Institutes of Health, National Heart, Lung and Blood Institute [2T32HL007954]
- Directorate For Engineering
- Div Of Electrical, Commun & Cyber Sys [824129] Funding Source: National Science Foundation
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Arrays of electrodes for recording and stimulating the brain are used throughout clinical medicine and basic neuroscience research, yet are unable to sample large areas of the brain while maintaining high spatial resolution because of the need to individually wire each passive sensor at the electrode-tissue interface. To overcome this constraint, we developed new devices that integrate ultrathin and flexible silicon nanomembrane transistors into the electrode array, enabling new dense arrays of thousands of amplified and multiplexed sensors that are connected using fewer wires. We used this system to record spatial properties of cat brain activity in vivo, including sleep spindles, single-trial visual evoked responses and electrographic seizures. We found that seizures may manifest as recurrent spiral waves that propagate in the neocortex. The developments reported here herald a new generation of diagnostic and therapeutic brain-machine interface devices.
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