Journal
NATURE NEUROSCIENCE
Volume 14, Issue 9, Pages 1118-1120Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2880
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Funding
- US National Institutes of Health [R01 NS045130-05]
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The thalamic reticular nucleus (TRN) is hypothesized to regulate neocortical rhythms and behavioral states. Using optogenetics and multi-electrode recording in behaving mice, we found that brief selective drive of TRN switched the thalamocortical firing mode from tonic to bursting and generated state-dependent neocortical spindles. These findings provide causal support for the involvement of the TRN in state regulation in vivo and introduce a new model for addressing the role of this structure in behavior.
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