Journal
NATURE NEUROSCIENCE
Volume 14, Issue 6, Pages 685-687Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2820
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Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan [16688006, 18688020, 21780121, 16108004, 20380183]
- Research and Development Program for New Bioindustry Initiatives
- Ajinomoto Amino Acid Research Program
- US National Institute on Deafness and Other Communication Disorders [R03 DC011143]
- Grants-in-Aid for Scientific Research [18688020, 16688006, 16108004, 21780121] Funding Source: KAKEN
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Functional diversification of taste cells is crucial for proper discrimination of taste qualities. We found the homeodomain protein Skn-1a (Pou2f3) to be expressed in sweet, umami and bitter taste cells. Skn-1a-deficient mice lacked electrophysiological and behavioral responses to sweet, umami and bitter tastes, as a result of a complete absence of sweet, umami and bitter cells and the concomitant expansion of sour cells. Skn-1a is critical for generating and balancing the diverse composition of taste cells.
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