Journal
NATURE NEUROSCIENCE
Volume 14, Issue 3, Pages 279-284Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2708
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Funding
- Howard Hughes Medical Institute Funding Source: Medline
- NINDS NIH HHS [K99 NS076364] Funding Source: Medline
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Many proteins have been implicated in synaptic and experience-dependent plasticity. However, few demonstrate the exquisite regulation of expression and breadth of functional importance as the immediate early gene product Arc. Here we review and attempt to synthesize the disparate views of Arc in neuronal function. The main conclusion garnered from this body of work is that Arc is a critical effector molecule downstream of many molecular signaling pathways and that dysregulation of Arc expression can have dire consequences for normal brain function.
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