Journal
NATURE NEUROSCIENCE
Volume 14, Issue 10, Pages 1237-1239Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2920
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Funding
- European Union [223326, 223524]
- EXTRAPLAST IIT project
- Telethon project [GGP09196]
- MIUR
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miR-132 is a CREB-induced microRNA that is involved in dendritic spine plasticity. We found that visual experience regulated histone post-translational modifications at a CRE locus that is important for miR-212 and miR-132 cluster transcription, and regulated miR-132 expression in the visual cortex of juvenile mice. Monocular deprivation reduced miR-132 expression in the cortex contralateral to the deprived eye. Counteracting this miR-132 reduction with an infusion of chemically modified miR-132 mimic oligonucleotides completely blocked ocular dominance plasticity.
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