Journal
NATURE NEUROSCIENCE
Volume 14, Issue 10, Pages 1240-1242Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2909
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Funding
- US National Eye Institute [1F32EY020066-01]
- Helmholtz Young Investigator program [HZ-NG-607]
- Simons Foundation
- US National Institutes of Health [EY017098, EY007023]
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Using quantitative analyses, we identified microRNAs (miRNAs) that were abundantly expressed in visual cortex and that responded to dark rearing and/or monocular deprivation. The most substantially altered miRNA, miR-132, was rapidly upregulated after eye opening and was delayed by dark rearing. In vivo inhibition of miR-132 in mice prevented ocular dominance plasticity in identified neurons following monocular deprivation and affected the maturation of dendritic spines, demonstrating its critical role in the plasticity of visual cortex circuits.
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