Journal
NATURE NEUROSCIENCE
Volume 14, Issue 6, Pages 691-693Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2809
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Funding
- Centre National de la Recherche Scientifique
- Conseil Regional d'Aquitaine
- European Commission [LSHM-CT-2005-019055]
- EMBO
- Fondation pour la Recherche Medicale
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Hippocampal mossy fiber synapses have been reported to lack NMDA receptor (NMDAR)-dependent long-term potentiation (LTP) of AMPA excitatory postsynaptic currents (EPSCs), unlike conventional glutamatergic synapses. An explanation for this difference may reside in the relatively low number of NMDARs at these synapses. Because mossy fiber synapses display LTP selective for NMDARs, we examined whether this would affect the plasticity rules at mossy fiber-CA3 synapses in mouse hippocampal slices. We found that LTP of NMDARs serves as a metaplastic switch making mossy fiber synapses competent for generating NMDAR-dependent LTP of AMPA EPSCs.
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