Journal
NATURE NEUROSCIENCE
Volume 14, Issue 9, Pages 1112-1114Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2893
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Funding
- American Health Assistance Foundation
- US National Institutes of Health/National Institute of Neurological Disorders and Stroke [R01 NS55804]
- Veteran's Affairs Office of Research and Development Medical Research Service
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Neurons adapt to long-lasting changes in network activity, both in vivo and in vitro, by adjusting their synaptic strengths to stabilize firing rates. We found that homeostatic scaling of excitatory synapses was impaired in hippocampal neurons derived from mice lacking presenilin 1 (Psen1(-/-) mice) or expressing a familial Alzheimer's disease-linked Psen1 mutation (Psen1(M146V)). These findings suggest that deficits in synaptic homeostasis may contribute to brain dysfunction in Alzheimer's disease.
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