Journal
NATURE NEUROSCIENCE
Volume 14, Issue 11, Pages 1390-1397Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2947
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Funding
- Interuniversity Attraction Poles
- FNRS (Fonds de la Recherche Scientifique)
- ARC (Actions de Recherche Concertees-Communaute francaise de Belgique)
- Flemish Government, the Fund for Scientific Research-Flemish Government [G.0677.09, G.0676.09]
- Belgian Science Policy [IUAP-P6/30]
- Association Francaise contre les Myopathies (AFM)
- Geneeskundige stichting Koningin Elisabeth
- Motor Neurone Disease Association [70/130]
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Blood vessels in the nervous system have traditionally been considered neutral bystanders that only passively adapt their structure and function in response to the needs of neural cells. Emerging evidence suggests, however, that vessels and angiogenic molecules actively participate in the pathogenesis of neurological disorders. Here we will discuss molecular insights into neurological disorders resulting either from excessive vessel growth (cerebral vascular malformations) or improper vessel regression (neurodegeneration and white matter lesions). These genetic insights offer alternative therapeutic options, some of which are being evaluated in the clinic.
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