Journal
NATURE NEUROSCIENCE
Volume 14, Issue 4, Pages 420-422Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2758
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- National Institute on Drug Abuse (US National Institutes of Health, Department of Health and Human Services)
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In a rat model of context-induced relapse to heroin, we identified sparsely distributed ventral medial prefrontal cortex (mPFC) neurons that were activated by the heroin-associated context. Selective pharmacogenetic inactivation of these neurons inhibited context-induced drug relapse. A small subset of ventral mPFC neurons formed neuronal ensembles that encode the learned associations between heroin reward and heroin-associated contexts; re-activation of these neuronal ensembles by drug-associated contexts during abstinence provoked drug relapse.
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